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3/4/2019 | UF Health-led ReMission Summit draws top experts, focuses on new brain tumor treatments

Top brain cancer experts from across the nation and beyond came together in Orlando last weekend at the invitation of University of Florida Health’s Duane Mitchell, M.D., Ph.D., and William A. Friedman, M.D., world leaders in the quest to significantly improve quality of life and long-term survival for patients fighting malignant brain tumors.

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1/22/2019 | Modulation of temozolomide dose differentially affects T cell response to immune checkpoint inhibition.

Glioblastomas (GBM) are malignant tumors of the brain. Many patients with GBM have profound suppressed immune systems due to the effects of the tumor. These patients can have T cell counts as low as patients with AIDS! The most common chemotherapy used for patients with GBM is called temozolomide and can cause further immunosuppression since it kills healthy immune cells as well as tumorous cells. Dr. Aida Karachi in our lab has found that temozolomide causes T cells to be dysfunctional. Our research shows that while TMZ can slow or even stop tumor growth, it comes at a price. This is why we need to work together to find more effective and less harmful treatments for cancers like GBM!

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1/16/2019 | Dr. Duane Mitchell named UF Health Cancer Center’s Top Influencer

At the UF Health Cancer Center‘s Cheers to the New Year event on Wednesday, Jan. 9, Duane Mitchell, M.D., Ph.D., was named the Center’s Top Influencer of 2018.

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